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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: In this work, we investigated whether the variant allele frequencies (VAFs) of ALK fusions can

Keywords： fusion     next-generation sequencing     fluorescence in situ hybridization     immunohistochemistry     variantallele frequency     intratumoral heterogeneity     targeted therapy    

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: We found a novel heterozygous missense variant (c.134G>C:p.G45A) for Clouston syndrome.Our data reveal that a novel variant (c.134G>C:p.G45A) plays a likely pathogenic role in this pedigree

Keywords： Clouston syndrome     whole exome sequencing     GJB6 gene     novel variant     unique phenotype    

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Studies on Malate Dehydrogenase Ⅱ (MDH Ⅱ ) Isozymes in Different Races of Apis mellifera ligustica

Chen Shenglu,Bao Xiuliang,Su Songkun,Liu Yanhe

Strategic Study of CAE 2000, Volume 2, Issue 1,   Pages 57-61

Abstract: honey bee (Ee) and Australian Italian honey bee (Eo) have been used to study the genotype, genotype frequency, allele frequency, heterozygous and homzygous degrees of the malate dehydrogenase Ⅱ (MDH Ⅱ ) isozymesThe allele frequencies are a (0.184), b (0.091), c (0.726) in Ea; a (0.067), b (0.090), c (0.717) inresults of test-independence show that there are significant differences in the distributions of genotype frequency, gene frequency, heterozygous and homozygous degrees among five races of Apis mellifera.

Keywords： races of Apis mellifera malate dehydrogenase (MDH)     genotype     allele frequency     heterozygosity    

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Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 576-580 doi: 10.1007/s11684-023-0991-0

Abstract: Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

Keywords： variant    

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BULKED SEGREGANT RNA SEQUENCING (BSR-SEQ) IDENTIFIES A NOVEL ALLELE ASSOCIATED WITH WEEPING TRAITS IN

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract: The Pm024074(PmUGT72B3) allele, belonging to the UDP-glycosyltransferase superfamily

Keywords： BSR-seq / PmUGT72B3 / Prunus mume / UDP-glycosyltransferase / weeping shoots / WGCNA    

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Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 808-814 doi: 10.1007/s11684-021-0878-x

Abstract: Here, we investigated five Chinese families with EB, and eight variants including a novel nonsense variant(c.47G>A, p.W16*) in LAMA3, a known recurrent variant (c.74C>T, p.P25L) in KRT5, 2 novelNotably, this study identified a nonsense variant in LAMA3 that causes EB within the Chinese populationand revealed that this variant resulted in a reduction in LAMA3 mRNA and protein expression levels

Keywords： epidermolysis bullosa     LAMA3     COL7A1     KRT5     Chinese families    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract: protein C activity resulting from a small insertion mutation c.848_849insGATGT in and a short deletion variant

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Exergy and exergoeconomic analyses for integration of aromatics separation with aromatics upgrading

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 2,   Pages 183-193 doi: 10.1007/s11705-022-2192-9

Abstract: Methanol to aromatics produces multiple products, resulting in a limited selectivity of xylene. Aromatics upgrading is an effective way to produce more valuable xylene product, and different feed ratios generate discrepant product distributions. This work integrates the aromatics separation with toluene disproportionation, transalkylation of toluene and trimethylbenzene, and isomerization of xylene and trimethylbenzene. Exergy and exergoeconomic analyses are conducted to give insights in the splitting ratios of benzene, toluene and heavy aromatics for aromatics upgrading. First, a detailed simulation model is developed in Aspen HYSYS. Then, 300 splitting ratio sets of benzene and toluene for conversion are studied to investigate the process performances. The results indicate that there are different preferences for the splitting ratios of benzene and toluene in terms of exergy and exergoeconomic performances. The process generates lower total exergy destruction when the splitting ratio of toluene varies between 0.07 and 0.18, and that of benzene fluctuates between 0.55 and 0.6. Nevertheless, the process presents lower total product unit cost with the splitting ratio of toluene less than 0.18 and that of benzene fluctuating between 0.44 and 0.89. Besides, it is found that distillation is the biggest contributor to the total exergy destruction, accounting for 94.97%.

Keywords： aromatics separation and upgrading     variant splitting ratios     total exergy destruction     total product    

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BULKED SEGREGANT RNA SEQUENCING (BSR-SEQ) IDENTIFIES A NOVEL ALLELE ASSOCIATED WITH WEEPING TRAITS IN

Xiaokang ZHUO, Tangchun ZHENG, Zhiyong ZHANG, Suzhen LI, Yichi ZHANG, Lidan SUN, Weiru YANG, Jia WANG, Tangren CHENG, Qixiang ZHANG

Frontiers of Agricultural Science and Engineering   Pages 196-214 doi: 10.15302/J-FASE-2020379

Abstract: The ( ) allele, belonging to the UDP-glycosyltransferase superfamily containing the coniferyl-alcohol

Keywords： BSR-seq     PmUGT72B3     Prunus mume     UDP-glycosyltransferase     weeping shoots     WGCNA    

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Research and development of a novel subunit vaccine for the currently circulating pseudorabies virus variant

Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 3,   Pages 216-222 doi: 10.15302/J-FASE-2015072

Abstract: Hence, this novel gB-based vaccine could be applied as an effective subunit vaccine to control PRV variant

Keywords： pseudorabies virus     glycoprotein B protein     subunit vaccine    

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A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

Frontiers of Structural and Civil Engineering doi: 10.1007/s11709-023-0006-x

Abstract: A frequency error estimation is presented for the isogeometric free vibration analysis of Kirchhoff–LoveBy analyzing the discrete isogeometric equations with the aid of harmonic wave assumption, the frequencyIn particular, the governing relationship of the continuum frequency for Kirchhoff–Love cylindrical shellsis naturally embedded into the frequency error measures without the need of explicit frequency expressionsNumerical results not only thoroughly verify the theoretical convergence rates of frequency solutions

Keywords： isogeometric analysis     Kirchhoff–Love cylindrical shell     free vibration     frequency error     convergence    

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Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

Frontiers in Energy 2013, Volume 7, Issue 4,   Pages 506-510 doi: 10.1007/s11708-013-0275-5

Abstract: The collision frequency function for aerosol particles has already been calculated for the free moleculeforce, electric force and molecular forces, created by particles themselves, recalculated the collision frequencyAttractive forces increase naturally the collision frequency, while repulsive forces decrease it.

Keywords： aerosol particles     collision frequency function     coagulation    

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Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

Frontiers in Energy 2009, Volume 3, Issue 2,   Pages 134-140 doi: 10.1007/s11708-009-0034-9

Abstract: The intent of this study is to investigate the fuel variability on the flickering frequency of diffusionIt was found that the low frequency oscillation of flow and flame structures depended only weakly onWhen a mixture of methane/propane at a ratio of 1:1 was used the peak flickering frequency was aroundMechanisms thought to produce changes in the dynamic response and frequency harmonics were discussed.

Keywords： fuel variability     flickering frequency     diffusion flames     dynamics of combustion    

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Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Frontiers in Energy 2012, Volume 6, Issue 2,   Pages 148-154 doi: 10.1007/s11708-012-0174-1

Abstract: Based on the analysis of frequency regulation, mathematic models for nuclear units in the grid are establishedThe relationship between different styles of frequency regulation and the allowable capacity of the nuclear

Keywords： nuclear units capacity     overspeed     primary frequency control (PFC)     second frequency control (SFC)    

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Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Frontiers of Mechanical Engineering 2009, Volume 4, Issue 3,   Pages 300-304 doi: 10.1007/s11465-009-0038-5

Abstract: To construct the spatial kinetic equation of an arterial tube and obtain its radial natural frequencyThe results show that the first-order frequency is 15.8 Hz and the obtained exact analytical solutions

Keywords： spatial kinematics     natural frequency     finite element method    

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Title Author Date Type Operation

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Journal Article

Studies on Malate Dehydrogenase Ⅱ (MDH Ⅱ ) Isozymes in Different Races of Apis mellifera ligustica

Chen Shenglu,Bao Xiuliang,Su Songkun,Liu Yanhe

Journal Article

Effectiveness of inactivated COVID-19 vaccine against the severity of Omicron variant

Journal Article

BULKED SEGREGANT RNA SEQUENCING (BSR-SEQ) IDENTIFIES A NOVEL ALLELE ASSOCIATED WITH WEEPING TRAITS IN

Journal Article

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism: a case report

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Exergy and exergoeconomic analyses for integration of aromatics separation with aromatics upgrading

Journal Article

BULKED SEGREGANT RNA SEQUENCING (BSR-SEQ) IDENTIFIES A NOVEL ALLELE ASSOCIATED WITH WEEPING TRAITS IN

Xiaokang ZHUO, Tangchun ZHENG, Zhiyong ZHANG, Suzhen LI, Yichi ZHANG, Lidan SUN, Weiru YANG, Jia WANG, Tangren CHENG, Qixiang ZHANG

Journal Article

Research and development of a novel subunit vaccine for the currently circulating pseudorabies virus variant

Yuzhou WANG,Tongyan WANG,He YAN,Fanli YANG,Linghua GUO,Qingyuan YANG,Xule HU,Feifei TAN,Yan XIAO,Xiangdong LI,Kegong TIAN

Journal Article

A frequency error estimation for isogeometric analysis of Kirchhoff–Love cylindrical shells

Journal Article

Calculation of collision frequency function for aerosol particles in free molecule regime in presence

Xiaowei LUO, Yannick BENICHOU, Suyuan YU

Journal Article

Fuel variability effect on flickering frequency of diffusion flames

Jizhao LI, Yang ZHANG

Journal Article

Capacity limitation of nuclear units in grid based on analysis of frequency regulation

Yiping DAI, Pan JIANG, Lin GAO, Weimin KAN, Xiaoqing XIAO, Ge JIN

Journal Article

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

Journal Article